The people at panic.com have created a FTP program: Transmit.  Transmit interfaces with FTP, SFTP, TLS/SSL, iDisk (WedDAV), and Amazon S3.  Transmit takes full advantage of the Cocoa API with ‘dock upload’, just drag a file to the dock to upload it, it includes a Dashboard widget, interfaces with Automator and Spotlight, and can edit remote files in any native applications.  Transmit 3 costs $29.95.